Constructions and advances of animal models of Pseudomonas aeruginosa infection.
10.3760/cma.j.cn112150-20220826-00843
- Author:
Yan Ying REN
1
;
Ying LIU
1
;
Bing FEI
1
;
Meng Yu GUO
1
;
Xin Wei LIU
2
;
Dong Mei LIU
2
;
Yong Wei LI
1
Author Information
1. The Second Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450001, China.
2. Medicine Laboratory Center of Henan Province Hospital of Traditional Chinese Medicine, Henan Provincial Key Laboratory of Antibiotics-Resistant Bacterial Infection Prevention & Therapy with Traditional Chinese Medicine, The Key Laboratory of Pathogenic Microbes & Antimicrobial Resistance Surveillance of Zhengzhou, Zhengzhou 450002, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Animals;
Pseudomonas Infections/microbiology*;
Models, Animal;
Virulence;
Pseudomonas aeruginosa;
Disease Models, Animal
- From:
Chinese Journal of Preventive Medicine
2023;57(6):929-934
- CountryChina
- Language:Chinese
-
Abstract:
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogenic bacterium with complex pathogenesis and drug resistance mechanisms. It has high morbidity and mortality and can cause acute and chronic infections in immunocompromised individuals, with lung infections, wound infections, and bloodstream infections being the most common. The animal infection model of P. aeruginosa is of great value for in-depth research on the pathogenicity, drug resistance, and therapeutic measures of P. aeruginosa by simulating the pathways of human bacterial infections. This article firstly summarizes the selection, anesthesia, and disposal of experimental animals in the construction of animal models of P. aeruginosa infection, and then reviews the methods of construction, model evaluation, and applications of animal models of P. aeruginosa pulmonary infection, wound infection, and bloodstream infection, in order to provide a reference for scientific research related to P. aeruginosa infectious diseases.
