Association between cognitive impairment and main metals among oldest old aged 80 years and over in China.
10.3760/cma.j.cn112150-20230215-00111
- Author:
Yi Dan QIU
1
;
Yan Bo GUO
2
;
Zhen Wei ZHANG
3
;
Sai Sai JI
3
;
Jin Hui ZHOU
3
;
Bing WU
4
;
Chen CHEN
3
;
Yuan WEI
5
;
Cong DING
3
;
Jun WANG
3
;
Xu Lin ZHENG
4
;
Zhu Chun ZHONG
1
;
Li hong YE
6
;
Guang Di CHEN
7
;
Yue Bin LYU
3
;
Xiao Ming SHI
1
Author Information
1. School of Public Health, Zhejiang University, Hangzhou 310030, China China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
2. School of Public Health, Jilin University, Changchun 132000, China.
3. China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
4. China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
5. China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China School of Public Health, Jilin University, Changchun 132000, China.
6. China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
7. School of Public Health, Zhejiang University, Hangzhou 310030, China.
- Publication Type:Journal Article
- MeSH:
Aged, 80 and over;
Female;
Humans;
Selenium;
Cohort Studies;
Cross-Sectional Studies;
Metals/analysis*;
Cognitive Dysfunction/epidemiology*;
China/epidemiology*
- From:
Chinese Journal of Preventive Medicine
2023;57(6):849-856
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To identify the main metals involved in cognitive impairment in the Chinese oldest old, and explore the association between these metal exposures and cognitive impairment. Methods: A cross-sectional study was conducted on 1 568 participants aged 80 years and older from Healthy Aging and Biomarkers Cohort Study (2017 to 2018). Fasting venous blood was collected to measure the levels of nine metals (selenium, lead, cadmium, arsenic, antimony, chromium, manganese, mercury, and nickel). The cognitive function of these participants was evaluated by using the Chinese version of the Mini-Mental State Examination (CMMSE). The random forest (RF) was applied to independently identify the main metals that affected cognitive impairment. The multivariate logistic regression model and restricted cubic splines (RCS) model were used to further verify the association of the main metals with cognitive impairment. Results: The age of 1 568 study subjects was (91.8±7.6) years old, including 912 females (58.2%) and 465 individuals (29.7%) with cognitive function impairment. Based on the RF model (the out-of-bag error rate was 22.9%), the importance ranking of variables was conducted and the feature screening of five times ten-fold cross-validation was carried out. It was found that selenium was the metal that affected cognitive function impairment, and the other eight metals were not included in the model. After adjusting for covariates, the multivariate logistic regression model showed that with every increase of 10 μg/L of blood selenium levels, the risk of cognitive impairment decreased (OR=0.921, 95%CI: 0.889-0.954). Compared with the lowest quartile(Q1) of blood selenium, the ORs (95%CI) of Q3 and Q4 blood selenium were 0.452 (0.304-0.669) and 0.419 (0.281-0.622) respectively. The RCS showed a linear dose-response relationship between blood selenium and cognitive impairment (Pnonlinear>0.05). Conclusion: Blood selenium is negatively associated with cognitive impairment in the Chinese oldest old.
