Advances in basic research on choline and central nervous system development and related disorders.
10.3760/cma.j.cn112150-20220531-00548
- Author:
Zheng Long XIA
1
;
Xu Ying TAN
1
;
Yan Yan SONG
1
Author Information
1. Department of Child Health Care, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Choline/metabolism*;
Phosphatidylcholines/metabolism*;
Central Nervous System/metabolism*
- From:
Chinese Journal of Preventive Medicine
2023;57(5):793-800
- CountryChina
- Language:Chinese
-
Abstract:
Choline is an essential nutrient that plays an integral role in all stages of the life cycle, with increasing interest in the relationship between choline and neurodevelopment. Choline is a major component in the synthesis of phospholipids, phosphatidylcholine and sphingolipids, and is an essential nutrient for methyl metabolism, acetylcholine synthesis and cell signaling. Choline plays an important role in neurogenesis and neural migration during fetal development, potentially influencing the development and prognosis of neurological disorders, but its mechanism of action is not yet clear. This article reviews the source and metabolism of choline, the effects and mechanism of choline on neurodevelopment and central nervous system related disorders.
