Persistence follow-up of immune memory to hepatitis B vaccine among infants with non- and low-response to primary vaccination after revaccination with three doses.
10.3760/cma.j.cn112150-20220511-00468
- VernacularTitle:乙型肝炎疫苗初次免疫低/无应答婴儿再免后的免疫记忆持久性随访观察
- Author:
Jing Jing LYU
1
;
Bing Yu YAN
2
;
Yi FENG
2
;
Xin MENG
2
;
Xue ZHAO
3
;
Xuan DOU
3
;
Xiao Feng LIANG
4
;
Fu Zhen WANG
5
;
Ai Qiang XU
1
;
Li ZHANG
1
Author Information
1. Expanded Program Immunizatin Division, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China School of Pubic Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
2. Expanded Program Immunizatin Division, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.
3. School of Pubic Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
4. School of Medicine, Jinan University, Guangzhou 510632, China.
5. Center for National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Child;
Humans;
Infant;
Hepatitis B Vaccines;
Immunization, Secondary;
Hepatitis B Surface Antigens;
Immunologic Memory;
Follow-Up Studies;
Vaccination;
Hepatitis B/prevention & control*;
Hepatitis B Antibodies
- From:
Chinese Journal of Preventive Medicine
2023;57(5):732-735
- CountryChina
- Language:Chinese
-
Abstract:
This study followed up the immune memory after 3-dose revaccination among infants with non-and low-response following primary hepatitis B (HepB) vaccination. About 120 children without self-booster doses were finally included who had anti-HBs<10 mIU/ml (anti-HBs negative) at the time of follow-up, of whom 86 children completed blood sampling and anti-HBs testing. Before the challenge dose, all 86 children were negative for anti-HBs, and the GMC of anti-HBs was<10 mIU/ml. The seropositive conversion rate of anti-HBs was 100% and the GMC of anti-HBs was 886.11 (95%CI: 678.15-1 157.84) mIU/ml after the challenge dose. Compared with those with GMC<7 mIU/ml before the challenge dose, infants with GMC>7 mIU/ml had a higher anti-HBs level after the challenge dose. The β value (95%CI) was 0.82 (0.18-1.46) (P=0.012). Compared with those with GMC<1 000 mIU/ml at primary vaccination, infants with GMC≥1 000 mIU/ml had a higher anti-HBs level after the challenge dose. The β value (95%CI) was 0.78 (0.18-1.38)(P=0.012). The results showed a stronger immune memory was found at 9 years after revaccination among infants with non-and low-response to HepB.
