Association between serum lysophosphatidylcholine level and elderly health index in older people from longevity areas of Guangxi Province.
10.3760/cma.j.cn112150-20221124-01144
- VernacularTitle:广西长寿地区老年人血清溶血磷脂酰胆碱水平与老年健康指数的关联研究
- Author:
Heng Shuo LIU
1
;
Zhu WU
1
;
Rui Yue YANG
1
;
Guan Zhou CHEN
1
;
Ying LI
2
;
Qi ZHOU
1
;
Hui Ping YUAN
1
;
Ze YANG
1
;
Liang SUN
1
Author Information
1. The Key Laboratory of Geriatrics/Beijing Institute of Geriatrics/Institute of Geriatric Medicine/Chinese Academy of Medical Sciences/Beijing Hospital/National Center of Gerontology of National Health Commission,Beijing 100730, China.
2. Department of Geriatrics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Middle Aged;
Humans;
Female;
Aged, 80 and over;
Lysophosphatidylcholines;
Risk Factors;
China;
Longevity;
Surveys and Questionnaires;
Triglycerides
- From:
Chinese Journal of Preventive Medicine
2023;57(5):649-653
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between serum lysophosphatidylcholine (LPC) level and the health index of the elderly. Methods: A total of 251 subjects were selected from the 2016 baseline survey of the Yongfu Longevity Cohort in Guangxi Province among whom 66, 63 and 122 were in the young and middle-aged group (≤59 years old), the young group (60-89 years old) and the longevity group (≥90 years old), respectively. Demographic data were collected and related indicators of height, weight, blood pressure and lipid metabolism were measured. The cognitive and physical functions of the elderly were assessed by the results of the simple mental state scale and the daily living activity scale to construct the health index of the elderly. The serum levels of LPC16∶0, LPC18∶0, LPC18∶1 and LPC18∶2 were determined by liquid chromatography-tandem mass spectrometry, and the differences among different ages and health status groups were compared. The logistic regression model was used to analyze the relationship between the serum LPC level and the health index of the elderly. Results: With the increase in age, the proportion of female subjects increased, and the rate of smoking and drinking decreased. BMI, TC, TG, LDL-C, diastolic blood pressure, and the four LPCs levels decreased with the increase of age, and systolic blood pressure levels increased with the increase of age (all P values<0.05). There was no significant difference in HDL-C levels among age groups (P>0.05). With the decline of health status in the elderly, serum levels of LPC16∶0, LPC18∶0, LPC18∶1 and LPC18∶2 showed a downward trend (all P values<0.001). After adjusting for age and gender, only LPC18∶0 was associated with the health status in old age [OR (95%CI): 0.48 (0.25-0.92)]. For every 1 standard deviation (16.87 nmol/L) increase in serum LPC18∶0 concentration, the risk of poor health status in old age decreased by 52%. Conclusion: Serum LPC18∶0 was associated with the health status in old age independent of age and sex.
