Association of hs-CRP with frailty and its components among the elderly over 65 years old in 9 longevity areas of China.
10.3760/cma.j.cn112150-20221202-01171
- VernacularTitle:中国9个长寿地区≥65岁老年人超敏C反应蛋白水平与虚弱及其组分的关联研究
- Author:
Jun Xin LIU
1
;
Yuan WEI
2
;
Jin Hui ZHOU
2
;
Jun WANG
2
;
Hao Can SONG
2
;
Xin Wei LI
2
;
Chang Zhen XIANG
1
;
Yi Bo XU
1
;
Cong DING
2
;
Zhen Yu ZHONG
3
;
Zheng ZHANG
2
;
Yu Fei LUO
2
;
Feng ZHAO
2
;
Chen CHEN
2
;
Jing Bo PI
3
Author Information
1. China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China School of Public Health, China Medical University, Shenyang 110001, China.
2. China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
3. School of Public Health, China Medical University, Shenyang 110001, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Aged;
Aged, 80 and over;
C-Reactive Protein/analysis*;
Frailty/epidemiology*;
Cohort Studies;
Cross-Sectional Studies;
China/epidemiology*
- From:
Chinese Journal of Preventive Medicine
2023;57(5):626-633
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the association of the levels of high sensitivity C-reactive protein (hs-CRP) with frailty and its components among the elderly over 65 years old in 9 longevity areas of China. Methods: Cross-sectional data from the Health Ageing and Biomarkers Cohort Study (HABCS, 2017-2018) were used and the elderly over 65 years old were included in this study. Through questionnaire interview and physical examination, the information including demographic characteristics, behavior, diet, daily activity, cognitive function, and health status was collected. The association between hs-CRP and frailty and its components in the participants was analyzed by multivariate logistic regression model and restrictive cubic spline. Results: A total of 2 453 participants were finally included, the age was (84.8±19.8) years old. The median hs-CRP level was 1.13 mg/L and the prevalence of frailty was 24.4%. Compared with the low-level group (hs-CRP<1.0 mg/L), the OR (95%CI) value of the high-level group (hs-CRP>3.0 mg/L) was 1.79 (1.35-2.36) mg/L. As for the components, the hs-CRP level was also positively associated with ADL disability, IADL disability, functional limitation and multimorbidity. After adjusting for confounding factors, compared with the low-level group, the OR (95%CI) values of the high-level group for the four components were 1.68 (1.25-2.27), 1.88 (1.42-2.50), 1.68 (1.31-2.14) and 1.39 (1.12-1.72), respectively. Conclusion: There is a positive association between the levels of hs-CRP and the risk of frailty among the elderly over 65 years old in 9 longevity areas of China. The higher hs-CRP level may increase the risk of frailty by elevating the risk of four physical functional disabilities, namely ADL disability, IADL disability, functional limitation and multimorbidity.
