Exposure level of neonicotinoid pesticides and their metabolites in pregnant women in the suburb of Shanghai.
10.3760/cma.j.cn112150-20220617-00621
- VernacularTitle:上海市城郊孕妇新烟碱类杀虫剂及其代谢物暴露水平研究
- Author:
Yuan Ping WANG
1
;
Lin Ying WU
2
;
Yi WANG
1
;
Dong Liang XUAN
2
;
Jing TIAN
2
;
Zi Chen YANG
1
;
Ming Hui HAN
1
;
He Xing WANG
1
;
Qian PENG
2
;
Qing Wu JIANG
3
Author Information
1. Department of Nutrition and Hygiene, School of Public Health, Fudan University, Shanghai 200032, China.
2. Department of Chemical Laboratory , Jiading District Center for Disease Control and Prevention, Shanghai 201899, China.
3. Department of Epidemiology and Health Statistics, School of Public Health, Fudan University, Shanghai 200032, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Female;
Pregnancy;
Pesticides/analysis*;
Pregnant Women;
China;
Neonicotinoids/analysis*;
Insecticides
- From:
Chinese Journal of Preventive Medicine
2023;57(5):741-746
- CountryChina
- Language:Chinese
-
Abstract:
In 2021, a total of 151 pregnant women were selected from the suburb of Shanghai. A questionnaire survey was conducted to obtain data about maternal age, gestational week, total annual household income, education level and passive smoking among pregnant women and one spot urine was collected. The concentrations of eight neonicotinoid pesticides and four metabolites in urine were measured by ultra-high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry. The differences in detection frequencies and concentrations of neonicotinoid pesticides and their metabolites among pregnant women with different characteristics were compared, and the influencing factors of the detection of neonicotinoid pesticides in urine were analyzed. The results showed that at least one neonicotinoid pesticide was detected in 93.4% (141 samples) of urine samples. The detection frequencies of N-desmethyl-acetamiprid, clothianidin, thiamethoxam, and N-desmethyl-clothianidin were high, about 78.1% (118 samples), 75.5% (114 samples), 68.9% (104 samples), and 44.4% (67 samples), respectively. The median concentration of the sum of all neonicotinoid pesticides was 2.66 μg/g. N-desmethyl-acetamiprid had the highest detection concentration with a median concentration of 1.04 μg/g. A lower urinary detection frequency of imidacloprid and its metabolites was seen in pregnant women aged 30-44 years [OR (95%CI): 0.23 (0.07-0.77)]. A higher detection frequency of clothianidin and its metabolites was seen in pregnant women with per capita annual household income≥100 000 yuan [OR (95%CI): 6.15 (1.56-24.28)]. There was widespread exposure to neonicotinoid pesticides and their metabolites in pregnant women from the suburb of Shanghai, which might pose potential health risks to pregnant women, and maternal age and household income were potential influencing factors of the exposure to neonicotinoid pesticides.
