Comparison of Microemulsion and Solvent Evaporation Technique for Solubility Enhancement of Amlodipine Besylate
https://doi.org/10.47836//mjmhs18.4.19
- Author:
Raja Nurul Batrisyia Hamzah
1
;
Long Chiau Ming
2
;
A.B.M. Helal Uddin
3
;
Zaidul Islam Sarker
3
;
Kai Bin Liew
1
;
Yik Ling Chew
4
Author Information
1. Department of Pharmaceutical Technology and Industry, Faculty of Pharmacy, University of Cyberjaya, 63000 Cyberjaya, Selangor, Malaysia
2. PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Brunei Darussalam
3. Faculty of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan, Pahang, Malaysia
4. Faculty of Pharmaceutical Sciences, UCSI University. No 1, Jalan Menara Gading, UCSI Heights, 56000 Cheras, Kuala Lumput, Malaysia
- Publication Type:Journal Article
- Keywords:
Amlodipine Besylate, Solvent Evaporation Method, Microemulsion, Solubility Enhancement
- From:Malaysian Journal of Medicine and Health Sciences
2022;18(No.4):135-140
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Amlodipine besylate is a calcium channel blocker indicated for hypertension and angina. It is described as slightly soluble in water and due to its limited solubility, it may result in poor bioavailability. The aim of
this study is to enhance the solubility of amlodipine besylate using solvent evaporation method and microemulsion
technique and to compare the two methods. Method: Solid dispersions (SD) of amlodipine besylate were developed
by employing solvent evaporation method. PEG6000 was the polymer of choice and different drug:polymer ratios
were used. Evaluation of the prepared SDs include solubility studies, dissolution studies and scanning electron microscopy (SEM). As for the microemulsion technique, microemulsions were prepared by phase titration method and
the optimized microemulsion formulation was then characterized for solubility studies and dissolution studies. Results: SD3 with drug:polymer ratio of 1:4 achieved the highest solubility which was 96.97 mg/ml ± 0.92 whereas the
solubility of the optimized microemulsion was found to be 112.54 mg/ml ± 0.92. In solvent evaporation method, as
the drug:polymer ratio increases, the solubility and dissolution rate of SDs increases. Conclusion: The two methods
had significantly enhance the solubility of amlodipine besylate however the microemulsion technique showed better
solubility profile.
- Full text:11.2022my1307.pdf
