Expression of Killer Cell Immunoglobulin-like Receptors (KIR) in Sex-associated Malignancies
https://doi.org/10.47836//mjmhs18.4.14
- Author:
Norfarazieda Hassan
1
,
2
;
Lee Le Jie
3
;
Tan Jun Hao
2
,
3
;
Siti Zuleha Idris
3
;
Hishamshah Mohd Ibrahim
4
;
Raudhawati Osman
5
;
Seow Heng Fong
3
;
Norhafizah Mohtaruddin
3
;
Andi Anggeriana Andi Asri
6
;
Maha Abdullah
3
Author Information
1. Regenerative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Bertam, Kepala Batas, Pulau Pinang&
2. UPM-MAKNA Cancer Research Laboratory, Institute of Biosciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor
3. Immunology Unit, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor&
4. Paediatric Department, Institute of Paediatric, Hospital Kuala Lumpur, 50586 Kuala Lumpur
5. Haematology Unit, Hospital Kuala Lumpur, 50586 Kuala Lumpur
6. Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang Selangor
- Publication Type:Journal Article
- Keywords:
Sex, NK cells, Killer-cell immunoglobulin-like receptors (KIR), Acute lymphoblastic leukemia (ALL), Ovarian cancer (OC)
- From:Malaysian Journal of Medicine and Health Sciences
2022;18(No.4):96-103
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Sex shapes immune response with possible consequence on tumor immune escape. Acute lymphoblastic leukemia (ALL) predominates in males while ovarian cancer (OC) occurs in females. NK cells essential for
tumor killing may have male preponderance. Association of sex, NK cell activity and malignancies is unclear. We
hypothesize that sex differentially affects KIR expressions in sex-biased cancers. Method: Expression of inhibitory
(KIR2DL1-5 and KIR3DL1-3) and activating (KIR2DS1-2 and 4-5 and KIR3DS1) genes in B-, T-cell ALL, OC and normal controls were determined by reverse-transcription polymerase-chain-reaction. Result: All normal males (but not
females) expressed the framework genes and generally maintained haplotype A, except KIR3DL1. Normal females
expressed more activating KIRs. Frequencies of KIR2DL1, 2DL4 and 2DS2 were significantly reduced among ovarian
cancer patients. Sex difference in frequencies of KIR expression was not detected in ALL as majority were undetectable except framework gene KIR3DL2, was more frequent among T-ALL. Conclusion: Cancers may be associated
with reduced KIR expression and influence of sex requires investigation.
- Full text:11.2022my1302.pdf
