Identification of Synthetic Cannabinoid New Psychoactive Substances 4F-MDMB-BUTINACA and MDMB-4en-PINACA.
10.12116/j.issn.1004-5619.2020.300501
- Author:
Kua Dou WANG
1
;
Xiao Liang YUAN
2
;
Yu Rong ZHANG
1
;
Jun Jian HU
2
;
Fang Qi CAO
2
;
Yong Sheng CHEN
1
Author Information
1. Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China.
2. Shanghai Research Institute of Criminal Science and Technology, Shanghai 200083, China.
- Publication Type:Journal Article
- Keywords:
forensic medicine;
toxicological analysis;
new psychoactive substance;
Fourier transform infrared spectrum （FTIR）;
gas chromatography-mass spectrometry （GC-MS）;
high resolution mass spectrometry;
nuclear magnetic resonance spectroscopy （NMR）;
synthetic cannabinoid
- MeSH:
Cannabinoids;
Gas Chromatography-Mass Spectrometry;
Illicit Drugs;
Magnetic Resonance Spectroscopy;
Mass Spectrometry
- From:
Journal of Forensic Medicine
2021;37(4):505-510
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a method that combines a series of techniques including Fourier transform infrared spectrum （FTIR）, gas chromatography-mass spectrometry （GC-MS）, high resolution mass spectrometry and nuclear magnetic resonance spectroscopy （NMR） for identification of unknown substances. Methods The unknown samples （off-white powder and yellow crystal） seized in the actual cases were detected by FTIR, GC-MS （methanol as solvent）, high resolution mass spectrometry （methanol as solvent） and NMR （deuterated methanol as solvent）. Results The mass spectrum characteristic ions m/z of the main components in the samples measured by GC-MS were 219 （base peak）, 363, 307, 304, 275, 145, 131 and 213 （base peak）, 357, 301, 298, 269, 185, 171, 145 and 131, respectively. The accurate mass numbers [M+H]+ measured by high resolution mass spectrometry were 364.203 61 and 358.212 34, respectively. The unknown samples were identified as synthetic cannabinoid new psychoactive substances 4F-MDMB-BUTINACA and MDMB-4en-PINACA after data consultation and database retrieval and comparison, combined with infrared analysis and mass spectrometry data analysis, and their structures were confirmed by 1H-NMR. Conclusion The established multi-technology joint identification method can be used to identify 4F-MDMB-BUTINACA and MDMB-4en-PINACA in unknown samples. This method is fast, convenient, accurate, reliable and practical, and can provide reference for the identification of cases involving such substances in the future.
