Research Progress on Metabolite Identification of Synthetic Cannabinoid New Psychoactive Substances.
10.12116/j.issn.1004-5619.2021.310602
- Author:
Le LI
1
;
Jun Bo ZHAO
1
;
Hui YAN
1
;
Wan Hui LIU
2
;
Ping XIANG
1
;
He Jian WU
1
Author Information
1. Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
2. School of Pharmacy, Yantai University, Yantai 264005, Shandong Province, China.
- Publication Type:Review
- Keywords:
forensic medicine;
toxicological analysis;
new psychoactive substance;
synthetic cannabinoid;
metabolite;
model;
review
- MeSH:
Animals;
Caenorhabditis elegans;
Cannabinoids;
Chromatography, Liquid;
Microsomes, Liver/chemistry*;
Rats;
Zebrafish
- From:
Journal of Forensic Medicine
2021;37(4):459-459
- CountryChina
- Language:Chinese
-
Abstract:
Synthetic cannabinoids are currently a class of new psychoactive substances with the largest variety and most abused. Metabolite identification research can provide basic data for monitoring synthetic cannabinoids abuse, which is the current research hotspot. The main trend of structural modification of synthetic cannabinoid is to replace the fluorine atom on pentyl indole or indazole cyclopentyl with hydrogen atom, which greatly improves the biological activity of the compound. The main metabolic reactions include hydroxylation, fluoropentyl oxidative, ester hydrolyze, amide hydrolysis. Liquid chromatography-high resolution mass spectrometry has become the preferred choice for the structural identification of metabolites. This review mainly summarizes research on metabolism software prediction and human hepatocyte model, human liver microsomes model, rat in vivo model, zebrafish model and fungus C. elegans model in metabolite identification based on the structure and classification of synthetic cannabinoids.
