Forensic Application of Next Generation Sequencing Technology in the Typing of Y Chromosome Genetic Markers.
10.12116/j.issn.1004-5619.2020.501205
- Author:
Yue YANG
1
;
Rui Yang TAO
2
;
Min LI
2
;
Huan YU
2
;
Li Qin CHEN
1
;
Ya Li WANG
1
;
Cheng Tao LI
1
Author Information
1. Department of Forensic Medicine, Inner Mongolia Medical University, Hohhot 010030, China.
2. Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
- Publication Type:Journal Article
- Keywords:
forensic genetics;
next generation sequencing;
Y chromosome genetic markers;
review
- MeSH:
Chromosomes, Human, Y/genetics*;
DNA Fingerprinting;
Forensic Genetics;
Genetic Markers;
High-Throughput Nucleotide Sequencing;
Humans;
Microsatellite Repeats;
Technology;
Y Chromosome
- From:
Journal of Forensic Medicine
2021;37(1):91-98
- CountryChina
- Language:English
-
Abstract:
The paternal inheritance characteristics of Y chromosome have been widely used in the forensic genetics field to detect the genetic markers in the non-recombining block, and used in the studies such as, genetic relationship identification, mixed stain detection, pedigree screen and ethnicity determination. At present, capillary electrophoresis is still the most common detection technology. The commercial detection kits and data analysis and processing system based on this technology are very mature. However, the disadvantages of traditional detection technology have gradually appeared with the rapid growth of bio-information amount, which promotes the renewal of forensic DNA typing technology. In recent years, next generation sequencing （NGS） technology has developed rapidly. This technology has been applied to various fields including forensic genetics and has provided new techniques for the detection of Y chromosome genetic markers. This article describes the current situation and application prospects of the NGS technology in forensic Y chromosome genetic markers detection in order to provide new ideas for future judicial practice.
