Age-Related Changes of Material Mechanics and Bone Material Parameters of Rat Skulls.
10.12116/j.issn.1004-5619.2020.400814
- Author:
Man LI
1
;
Ming Jie LI
1
;
Jiang HUANG
1
;
Cui Yun LE
1
;
Yao WANG
1
;
Ling Qiang ZHAO
1
;
Cheng Fei WANG
1
;
Chang Wu WAN
1
;
Jia Wen WANG
1
Author Information
1. School of Forensic Medicine, Guizhou Medical University, Guiyang 550004, China.
- Publication Type:Journal Article
- Keywords:
forensic pathology;
biomechanics;
age;
skull;
material mechanics parameter;
bone material parameters;
rats
- MeSH:
Animals;
Biomechanical Phenomena;
Bone Density;
Male;
Rats;
Rats, Sprague-Dawley;
Skull/diagnostic imaging*
- From:
Journal of Forensic Medicine
2021;37(1):1-6
- CountryChina
- Language:English
-
Abstract:
Objective To study the relationship between material mechanics and bone material parameters of rat skulls and their correlation with age by examination of the parameters. Methods Forty-eight healthy male SD rats were divided into 2, 4, 6, 8, 17, 26, 52 and 104 week groups according to their age. Each group had six rats. The right cranium was compressed by KD Ⅱ-0.2 microcomputer controlled electronic universal testing machine, and material mechanics parameters （ultimate load, compression strength and compression modulus） were measured, then the skull slices were cut off and scanned by Micro-CT system to detect bone material parameters （skull thickness, bone mineral density, bone volume, and trabecular thickness）. Results The differences in ultimate load, compression strength and compression modulus among all groups had statistical significance （P<0.05）, and were positively correlated with age within 26 weeks （P<0.05）. The differences in skull thickness, bone mineral density, bone volume and trabecular thickness among all groups had statistical significance （P<0.05）, and were positively correlated with age within 52 weeks （P<0.05）. All material mechanics parameters were positively correlated with bone material parameters （P<0.05）. Conclusion There is a positive correlation between bone material parameters （skull thickness, bone mineral density, bone volume, trabecular thickness）, material mechanics parameter （skull ultimate load, compression strength, compression modulus） and age in a certain range, which can be used to infer age.
