Research Progress of Metabolomics in Forensic Pathology.
10.12116/j.issn.1004-5619.2020.03.010
- Author:
TieShuai DU
1
;
Mai Meng MENGXI
1
;
Xing YE
1
;
Chun Yan TU
1
;
Kai Di JIN
1
;
Shao Wen CHEN
1
;
Ning Guo LIU
2
;
Jian Hui XIE
1
;
Yi Wen SHEN
1
Author Information
1. Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
2. Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
- Publication Type:Review
- Keywords:
forensic pathology;
metabolomics;
postmortem interval;
cause of death;
review
- MeSH:
Autopsy;
Forensic Pathology/trends*;
Forensic Toxicology;
Humans;
Metabolomics;
Postmortem Changes
- From:
Journal of Forensic Medicine
2020;36(3):347-353
- CountryChina
- Language:English
-
Abstract:
Metabolomics is an interdisciplinary subject that rose in the post-genomic era, which focuses on quantitative study of the response of living organisms to outside stimulation and pathophysiological changes, as well as multiple dynamic response of the level of in vivo metabolites caused by genetic mutation. It is extensively used in basic research of system biology, materia medica, clinical medicine, etc. In the forensic field, metabolomics mainly focuses on forensic toxicology, but with the generalization of certain techniques, it's foreseeable that metabolomics has a broad research prospect in forensic pathology. This article summarizes the major analysis techniques and methods of metabolomics, describes the research status of metabolomic techniques in the field of forensic pathology application research, including postmortem interval and death cause. Moreover, this article summarizes and discusses the potential applicable areas, in order to provide reference for relative research and application.
