Mitochondrial Damage due to Hypoxia and Its Forensic Significance.
10.12116/j.issn.1004-5619.2020.02.018
- Author:
Yi Kai HU
1
;
Heng ZHANG
1
;
Bi XIAO
2
;
Long CHEN
1
Author Information
1. Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
2. Shanghai Key Laboratory of Crime Scene Evidence, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China.
- Publication Type:Review
- Keywords:
forensic pathology;
mitochondria;
wounds and injuries;
hypoxia;
mechanical asphyxia;
review
- MeSH:
Asphyxia;
Forensic Pathology;
Humans;
Hypoxia;
Mitochondria;
Oxygen
- From:
Journal of Forensic Medicine
2020;36(2):243-248
- CountryChina
- Language:English
-
Abstract:
Mitochondria are the special organelle in eukaryotic cells. Their main functions are to synthesize energy required for cell activity by oxidative phosphorylation. Most of the oxygen absorbed by the body is consumed in the mitochondria. The precise diagnosis of mechanical asphyxia is one of the difficulties in forensic pathology practice. Forensic pathologists have been trying to find a reliable and sensitive marker for the diagnosis of mechanical asphyxia. Mitochondria are very sensitive to hypoxic environments, and the markers of mitochondrion damage can be used as a basis for the diagnosis of mechanical asphyxia. The purpose of this paper is to review the research progress on mitochondrial damage in hypoxic environments and to explore the possibility of using markers of mitochondrion damage in forensic pathological practice.
