Research Progress on the Molecular Mechanisms of Toxicology of Ethanol-Aconitine Induced Arrhythmia.
10.12116/j.issn.1004-5619.2020.01.022
- Author:
Mei Chen PAN
1
;
Xiao Wei ZHOU
2
;
Yan LIU
1
;
Yu Ning WANG
1
;
Xin Gang QIU
1
;
Shi Fan WU
1
;
Qian LIU
1
Author Information
1. Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
2. Hubei Chongxin Judicial Expertise Center, Wuhan 430403, China.
- Publication Type:Review
- Keywords:
forensic toxicology;
poisoning;
ethanol;
aconitine;
arrythmia;
review
- MeSH:
Aconitine;
Aconitum;
Arrhythmias, Cardiac;
Drugs, Chinese Herbal;
Ethanol;
Humans
- From:
Journal of Forensic Medicine
2020;36(1):115-119
- CountryChina
- Language:English
-
Abstract:
Aconitum is one of the most widely used Chinese herbal medicines, and aconitine is the major toxic component in it. Aconitine can induce a variety of arrhythmias, resulting in death. Acute ethanol consumption causes arrhythmia as well. Poisoning cases caused by aconitum medicinal liquor are frequently encountered in the practice of forensic medicine. The molecular mechanisms of myocardial toxicity of these two drugs have much in common, and both of them affect the sodium channel, calcium channel and potassium channel of myocardial cell membrane and so on. This paper analyzes and discusses the possible co-effects of ethanol-aconitine on cardiomyocyte channel proteins, by reviewing researches on the mechanism of cardiotoxicity of ethanol and aconitine in recent years, in order to provide ideas and references for the research on the molecular mechanism of arrhythmia caused by combined poisoning.
