Calculation of Likelihood Ratio for Identifying Half Sibling Relationship When Both Biological Mothers Participate.
10.12116/j.issn.1004-5619.2019.06.004
- Author:
Xue Ling OU
1
;
Hui Ling LU
1
;
Jian SHEN
1
;
Ning QU
1
;
Hao LIANG
1
Author Information
1. Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
- Publication Type:Journal Article
- Keywords:
forensic genetics;
autosome;
short tandem repeat;
likelihood ratio;
half sibling relations
- MeSH:
Alleles;
Female;
Forensic Genetics;
Genotype;
Humans;
Likelihood Functions;
Models, Genetic;
Mothers;
Population Groups;
Siblings
- From:
Journal of Forensic Medicine
2019;35(6):662-666
- CountryChina
- Language:English
-
Abstract:
Objective To derive the formulae for likelihood ratio （LR） calculation of half sibling relationships when both mothers participate. Methods Based on the fact that both biological mothers participate in the identification of half sibling relationship between the two individuals, test hypothesis for the identification of half sibling relationship was established. Conditional probability ratios of genetic evidence under null hypothesis and alternative hypothesis conditions were simplified, and then applied to a real case of half sibling relationship identification. At the same time, the LR of half sibling relationships under the assumption that only a single biological mother or none of the biological mothers participate were respectively calculated. Results In the cases of identification of half sibling relationship from same fathers, with no biological father involved, after the same genetic indicator test analysis, when both biological mothers participate in the identification, the accumulated LR value was higher than that of accumulated LR with only a single biological mother or no parents participating. Conclusion When the autosome STR test is used for the identification and analysis of half sibling relationship between two individuals, the calculation of LR is more simple, intuitive and operable with both mothers participating. The biological mothers should participate in the test as much as possible, otherwise the number of STR loci would need to be increased for a more specific conclusion.
