Identification of Tiletamine, Zolazepam and Their Metabolites in Drug Facilitated Sexual Assault by GC-QTOF-MS.
10.12116/j.issn.1004-5619.2019.05.013
- Author:
Si Yang HE
1
;
Fei Jun GONG
1
;
Ru LIAN
1
;
Zhen Hai SHENG
1
;
Jin Lun XU
1
;
Wen Juan SUN
1
;
Shui Qing ZHENG
1
Author Information
1. Shanghai Key Laboratory of Criminal Scene Evidence, Institute of Forensic Science of Shanghai Public Security Bureau, Shanghai 200083, China.
- Publication Type:Journal Article
- Keywords:
forensic toxicology;
sex offenses;
tiletamine;
zolazepam;
gas chromatography;
quadrupole time of flight mass spectrometry;
drug facilitated
- MeSH:
Chromatography, High Pressure Liquid/methods*;
Forensic Toxicology/methods*;
Gas Chromatography-Mass Spectrometry/methods*;
Humans;
Sex Offenses;
Tandem Mass Spectrometry/methods*;
Tiletamine/blood*;
Zolazepam/blood*
- From:
Journal of Forensic Medicine
2019;35(5):581-585
- CountryChina
- Language:English
-
Abstract:
Objective To identify tiletamine, zolazepam and their metabolites in samples from drug facilitated sexual assault by gas chromatography-quadrupole time of flight mass spectrometry （GC-QTOF-MS）. Methods Urine samples of victims were collected, and detected by GC-QTOF-MS after liquid-liquid extraction and concentration. The molecular formula of fragments ions was identified by determination of accurate mass numbers, to detect related substances. Results Tiletamine, zolazepam, three metabolites of tiletamine and two metabolites of zolazepam were identified in urine samples from actual cases. Conclusion GC-QTOF-MS provides abundant and accurate information of fragment ions mass numbers, which can be used for qualitative identification of tiletamine, zolazepam and their metabolites in drug facilitated sexual assault.
