Relationship between Blood Acetaldehyde Concentration and Psychomotor Function of Individuals with Different ALDH2 Genotypes after Alcohol Consumption.
10.12116/j.issn.1004-5619.2019.05.012
- Author:
Yi YE
1
;
Fan CHEN
1
;
Hao WU
1
;
Shegn Nan LAN
1
;
Lan Rui JIANG
1
;
Ke Ke DAI
1
;
You Yi YAN
1
;
Lin YANG
1
;
Lin Chuan LIAO
1
Author Information
1. West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- Keywords:
forensic toxicology;
ethanol;
acetaldehyde;
acetaldehyde dehydrogenase;
polymorphism;
psychomotor function
- MeSH:
Acetaldehyde/metabolism*;
Alcohol Drinking/blood*;
Aldehyde Dehydrogenase/genetics*;
Aldehyde Dehydrogenase, Mitochondrial;
Aldehyde Oxidoreductases;
Ethanol/metabolism*;
Genotype;
Humans;
Polymorphism, Genetic/genetics*;
Psychomotor Performance/physiology*
- From:
Journal of Forensic Medicine
2019;35(5):576-580
- CountryChina
- Language:English
-
Abstract:
Objective To explore the change rules of blood ethanol and blood acetaldehyde concentration, the impairment of psychomotor functions of different acetaldehyde dehydrogenase （ALDH） 2 genotype individuals after alcohol consumption and the relationship among them. Methods The ALDH2 genotypes in seventy-nine healthy volunteers were obtained by SNaPshotTM method, then divided into ALDH2*1/*1 （wild type） and ALDH2*1/*2 （mutant type） group. After volunteers consumed 1.0 g/kg of alcohol, blood ethanol concentration and blood acetaldehyde concentration at a series of time points before and after alcohol consumption and psychomotor functions, such as, visual selective response time, auditory simple response time and tracking experiment were detected. Biphasic alcohol response questionnaires were collected. Results After alcohol consumption, ALDH2*1/*2 group's blood ethanol and blood acetaldehyde concentration reached the peak earlier than ALDH2*1/*1 group. Its blood acetaldehyde concentration was higher than that of ALDH2*1/*1 group, 1-6 h after alcohol consumption. The psychomotor functions, such as visual selective response time and auditory simple response time in ALDH2*1/*2 group were more significantly impaired than those in ALDH2*1/*1 group after alcohol consumption. There was no statistical significance between the two groups in excitement or sedation reactions （P>0.05）. Pearson correlation coefficient test showed that blood acetaldehyde concentration was related with psychomotor function. Conclusion There are significant differences between the psychomotor function of ALDH2 wild type and mutant type individuals after alcohol consumption estimated to be related to the difference in blood acetaldehyde concentration after alcohol consumption.
