Research Progress on Forensic Molecular Phenotyping in the Age of Precision Medicine.
10.12116/j.issn.1004-5619.2019.05.004
- Author:
Wen Ting ZHAO
1
;
Li JIANG
1
;
Cai Xia LI
1
Author Information
1. National Engineering Laboratory for Crime Scene Evidence Investigation and Examination, Key Laboratory of Forensic Genetics, Beijing Engineering Research Center of Crime Scene Evidence Examination, Ministry of Public Security, Institute of Forensic Science, Beijing 100038, China.
- Publication Type:Review
- Keywords:
forensic genetics;
phenotype;
precision medicine;
review
- MeSH:
DNA/genetics*;
DNA Fingerprinting;
Forensic Genetics;
Forensic Medicine/trends*;
Genetic Markers;
Genetic Testing;
Humans;
Phenotype;
Precision Medicine
- From:
Journal of Forensic Medicine
2019;35(5):525-530
- CountryChina
- Language:English
-
Abstract:
With the development of new technologies, such as whole genome sequencing and big data, many countries have constructed large cohorts as strategic resources for precision medicine study. Related studies have significantly promoted research progress in many fields, such as medicine and biology, creating the genetic testing industry. In the forensic field, characterization technologies for features, such as biogeographic ancestry, genetic genealogy and physical appearance have emerged and developed rapidly. Compared with traditional forensic DNA technology, the new technology can search for characteristics and provide clues, quickly becoming an important means to solve difficult cases such as cold cases and accumulated cases. This paper briefly reviews the current status of the construction of large cohorts at home and abroad, and the research progress of forensic molecular phenotyping in the context of precision medicine in the context of precision medicine.
