Research Progress on Chiral Separation Methods and Toxic Effects of Methamphetamine Enantiomers.
10.12116/j.issn.1004-5619.2019.03.015
- Author:
Ying Yi ZHANG
1
;
Liang LI
2
;
An De MA
1
;
Zheng Zheng ZHOU
1
Author Information
1. Department of Hygiene Inspection and Quarantine Science, School of Public Health, Southern Medical University, Guangzhou 510515, China.
2. Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
- Publication Type:Review
- Keywords:
forensic toxicology;
methamphetamine;
enantiomer;
toxicology;
review
- MeSH:
Central Nervous System Stimulants;
Humans;
Methamphetamine/chemistry*;
Stereoisomerism;
Substance Abuse Detection
- From:
Journal of Forensic Medicine
2019;35(3):337-343
- CountryChina
- Language:English
-
Abstract:
Methamphetamine （MAMP） is a kind of amphetamine-type stimulants （ATS） which contains one chiral carbon atom in its structure. Therefore a pair of enantiomers, S-（+）-MAMP and R-（-）-MAMP exist. R type and S type methamphetamines possess similar physicochemical properties, but has largely different pharmacological and toxic effects. S-（+）-MAMP is the main component of addictive drug "Ice" at present, seriously affecting human health and public safety. The separation analysis and mechanism of toxic effects discussions on MAMP are the current research focuses. This paper reviews the research progress of separation analysis methods and toxic effects of methamphetamine enantiomers to provide reference for forensic study and forensic practice.
