Research Progress on InDel Genetic Marker in Forensic Science.
10.12116/j.issn.1004-5619.2018.04.016
- Author:
Xiang SHENG
1
;
Yun BAO
2
;
Jia Shuo ZHANG
1
;
Min LI
2
;
Ya Nan LI
2
;
Qian Nan XU
2
;
Su Hua ZHANG
2
;
Cheng Tao LI
2
Author Information
1. Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China.
2. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
- Publication Type:Review
- Keywords:
forensic genetics;
genetic marker;
insertion/deletion;
review
- MeSH:
Alleles;
DNA/genetics*;
DNA Fingerprinting;
Forensic Genetics;
Genetic Markers;
INDEL Mutation;
Microsatellite Repeats;
Polymorphism, Single Nucleotide
- From:
Journal of Forensic Medicine
2018;34(4):420-427
- CountryChina
- Language:English
-
Abstract:
Genetic markers in forensic DNA typing experienced the variable number of tandem repeats （VNTR） sequences and the short tandem repeats （STR） sequences. With the emerge of sequencing technology, the third generation of genetic markers were found out, which usually have two alleles including single nucleotide polymorphism （SNP） and insertion/deletion （InDel）, also known as biallelic genetic markers. Because of the insertions or deletions of DNA fragments, InDel genetic marker reveals DNA fragment length polymorphism and widely distributes across the whole genome. InDel genetic marker is numerous and has the characteristics of STR and SNP genetic markers, which has been applied in the fields of genetics and anthropology. This review focuses on the research progress of InDel genetic marker in forensic science, aiming to review and summarize the main research findings in recent years and provide clues for future researches.
