Identification of New Designer Benzodiazepine Diclazepam in Drug Facilitated Sexual Assault.
10.12116/j.issn.1004-5619.2018.03.006
- Author:
Ping XIANG
1
;
Bao Hua SHEN
1
;
Hui YAN
1
;
Wei LIU
1
;
Min SHEN
1
;
He Jian WU
1
;
Xiana Yi ZHUO
1
Author Information
1. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
- Publication Type:Journal Article
- Keywords:
LC-QE;
benzodiazepine;
designer drugs;
diclazepam;
drug-facilitated sexual assault;
forensic toxicology
- MeSH:
Benzodiazepines/chemistry*;
Benzodiazepinones;
Chromatography, Liquid/methods*;
Designer Drugs/chemistry*;
Female;
Gas Chromatography-Mass Spectrometry/methods*;
Humans;
Male;
Mass Spectrometry/methods*;
Sex Offenses;
Substance Abuse Detection/methods*;
Toxicology/methods*
- From:
Journal of Forensic Medicine
2018;34(3):248-252
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To identify the new designer drugs which are totally unknown and not in the routine testing list by the technologies such as high-resolution mass spectrometry in drug facilitated sexual assault, in order to solve the problem in actual cases.
METHODS:The milky fluid from an actual case was extracted and analyzed using LC-QE, ¹H-NMR and GC-MS, respectively. The accurate masses and cluster ions isotope patterns of unknown compound were obtained by LC-QE. The molecular formula was confirmed as C₁₆H₁₂C₂N₂O based on the protons number of ¹H-NMR. The isomers diclazepam and 4-chlorodiazepam were separated and detected with GC-MS.
RESULTS:The new designer benzodiazepine as diclazepam in the milky fluid was identified. The results provided direct evidence for the investigation and qualitative analysis of such cases.
CONCLUSIONS:The combined application of various methods, including LC-QE, ¹H-NMR and GC-MS, can be used to detect unknown new psychoactive substances.
