Assessment on Application of 24 Y-STR Loci in Forensic Science.
10.12116/j.issn.1004-5619.2018.03.004
- Author:
Min LI
1
;
Lei HUANG
2
;
Xin Jie WANG
3
;
Yu Ling CHEN
4
;
Xiang SHENG
4
;
Ya Nan LI
4
;
Yun BAO
4
;
Lei JIANG
4
;
Ru Xin ZHU
4
;
Qian Nan XU
1
;
Jia Shuo ZHANG
4
;
Chegn Tao LI
1
;
Ying Nan BIAN
1
Author Information
1. Department of Forensic Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
2. Shandong Provincial Public Security Department, Jinan 250001, China.
3. Weifang Public Security Bureau, Weifang 261061, China.
4. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
- Publication Type:Journal Article
- Keywords:
Shandong;
Y-STR;
forensic genetics;
haplotype;
mutation rate
- MeSH:
Alleles;
China;
Chromosomes, Human, Y;
Forensic Genetics;
Forensic Sciences;
Genetic Variation;
Genetics, Population;
Haplotypes;
Humans;
Male;
Mutation Rate;
Population Groups
- From:
Journal of Forensic Medicine
2018;34(3):236-241
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To select a Y-STR marker system with strong haplotype identification ability, appropriate mutation rate and high compatibility and to assess its forensic application.
METHODS:The 24 Y-STR loci were tested by self-built fluorescent multiplex system, and the forensic assessment was conducted by 139 pairs of father-son samples collected in Jinan, Shandong province.
RESULTS:Totally 176 alleles were identified among the 24 Y-STR loci in the sample of 139 unrelated individuals labeled with father, and the gene diversity （GD） distributed between 0.083 7 （DYS645）-0.966 9 （DYS385a/b）. According to the 24 Y-STR loci, 139 different haplotypes were detected from 139 unrelated male individuals labeled with father in Han population of Shandong province and with no shared haplotype observed. The overall haplotype diversity （HD） was 1 and the discrimination capacity （DC） was 1. A total of 5 one-step mutations events were observed among the 24 Y-STR loci in 139 pairs of father-son. The average mutation rate was 0.001 5 [95% CI （0.000 5, 0.003 5）].
CONCLUSIONS:The system of 24 Y-STR loci shows a strong individual recognition ability and low mutation rate in the population in Jinan, Shandong province, and it has good application value in forensic science.
