Incidence and Risk Factors of Tuberculosis in Patients with Human Immunodeficiency Virus Infection.
10.3346/jkms.2013.28.3.374
- Author:
Jeong Hwan HWANG
1
;
Pyoeng Gyun CHOE
;
Nak Hyun KIM
;
Ji Hwan BANG
;
Kyoung Ho SONG
;
Wan Beom PARK
;
Eu Suk KIM
;
Sang Won PARK
;
Hong Bin KIM
;
Nam Joong KIM
;
Myoung Don OH
;
Kang Won CHOE
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. molder@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Tuberculosis;
Incidence;
Risk Factors;
HIV
- MeSH:
Adult;
CD4 Lymphocyte Count;
Female;
HIV Infections/*complications;
Humans;
Incidence;
Male;
Middle Aged;
Retrospective Studies;
Risk Factors;
Tuberculosis/complications/*epidemiology/mortality
- From:Journal of Korean Medical Science
2013;28(3):374-377
- CountryRepublic of Korea
- Language:English
-
Abstract:
Korea is a low prevalence country for human immunodeficiency virus (HIV) infection and has an intermediate tuberculosis (TB) burden. We previously reported that the incidence of TB in HIV-infected patients was 9.6 cases per 100 person-years (P-Y) between 1988 and 1997. The aims of the present study were to measure any change in incidence from the previous study, and to identify risk factors for TB in HIV-infected patients. We reviewed all medical records of HIV-infected patients who were followed-up in one tertiary hospital between 1998 and 2010. Over the total observation period of 5858.33 P-Y, TB developed in 70 patients (1.19 cases per 100 P-Y; 95% confidence interval [CI], 0.91-1.47 cases per 100 P-Y). Based on Poisson regression, one risk factor associated with TB was an initial CD4+ cell count below 200 cells/microliter (relative risk, 2.34; 95% CI, 1.47-3.73). Mean CD4+ cell counts of pulmonary, extrapulmonary, and both pulmonary and extrapulmonary TB were 179.8 cells/microliter, 138.3 cells/microliter, and 114.2 cells/microliter, respectively (P = 0.55). In conclusion, the incidence of TB in HIV-infected patients has decreased since the previous study. An initial CD4+ cell count below 200 cells/microliter is an independent risk factor for development of TB in HIV-infected patients.
