Significance of Hypoxia-related microRNA for Estimating the Cause of Mechanical Asphyxia Death.
10.3969/j.issn.1004-5619.2017.01.010
- Author:
Yan ZENG
1
;
Jian Long MA
1
;
Long CHEN
1
Author Information
1. Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.
- Publication Type:Review
- Keywords:
anoxia;
asphyxia;
cause of death;
forensic pathology;
microRNA;
review
- MeSH:
Accidents;
Airway Obstruction/physiopathology*;
Apoptosis;
Asphyxia/pathology*;
Cause of Death;
Death;
Forensic Medicine;
Humans;
Hypoxia/physiopathology*;
MicroRNAs/metabolism*;
Oxygen
- From:
Journal of Forensic Medicine
2017;33(1):38-41
- CountryChina
- Language:Chinese
-
Abstract:
Under hypoxia condition, microRNA （miRNA） can interact with transcription factors for regulating the cell metabolism, angiogenesis, erythropoiesis, cellular proliferation, differentiation and apoptosis. The biological processes above may play an important role in mechanical asphyxia death. This article reviews the regulating function of miRNA under hypoxia condition and the influence of hypoxia to biosynthesis of miRNA, which may provide some new ideas to the research of miRNA on determining the cause of mechanical asphyxia death in the field of forensic medicine.
