Research Progress on the Detection Method of DNA Methylation and Its Application in Forensic Science.
10.3969/j.issn.1004-5619.2017.03.017
- Author:
Yan Cha NIE
1
;
Li Juan YU
1
;
Hua GUAN
1
;
Ying ZHAO
1
;
Hai Bo RONG
1
;
Bo Wei JIANG
1
;
Tao ZHANG
1
Author Information
1. First Research Institute of the Ministry of Public Security of PRC, Beijing 100022, China.
- Publication Type:Review
- Keywords:
DNA methylation;
forensic genetics;
review;
third generation sequencing;
twins, monozygotic
- MeSH:
CpG Islands;
DNA Methylation/genetics*;
Epigenesis, Genetic;
Epigenomics;
Forensic Genetics/trends*;
Genetic Markers/genetics*;
Humans;
Sulfites;
Twins, Monozygotic/genetics*
- From:
Journal of Forensic Medicine
2017;33(3):293-300
- CountryChina
- Language:Chinese
-
Abstract:
As an important part of epigenetic marker, DNA methylation involves in the gene regulation and attracts a wide spread attention in biological auxology, geratology and oncology fields. In forensic science, because of the relative stable, heritable, abundant, and age-related characteristics, DNA methylation is considered to be a useful complement to the classic genetic markers for age-prediction, tissue-identification, and monozygotic twins' discrimination. Various methods for DNA methylation detection have been validated based on methylation sensitive restriction endonuclease, bisulfite modification and methylation-CpG binding protein. In recent years, it is reported that the third generation sequencing method can be used to detect DNA methylation. This paper aims to make a review on the detection method of DNA methylation and its applications in forensic science.
