Research Progress of the Relationship between the Expression of TAR DNA-binding Domain Protein 43 and Brain Injury.
10.3969/j.issn.1004-5619.2017.03.016
- Author:
Yao YE
1
;
Ru Bo LI
1
;
Shi Yu MA
2
;
Xue Ting WEI
2
;
Qi XU
2
Author Information
1. School of Forensic Medicine, China Medical University, Shenyang 110000, China.
2. School of Clinical Medicine, China Medical University, Shenyang 110122, China.
- Publication Type:Review
- Keywords:
TAR DNA-binding domain protein 43;
brain injuries;
forensic pathology;
review
- MeSH:
Brain Injuries/pathology*;
DNA;
DNA-Binding Proteins/metabolism*;
Humans
- From:
Journal of Forensic Medicine
2017;33(3):289-292
- CountryChina
- Language:Chinese
-
Abstract:
TAR DNA-binding domain protein 43 （TDP-43） is a highly conserved and widely expressed nuclear protein. Nowadays, the expression of TDP-43 can be found in most neurodegenerative diseases such as Alzheimer's disease, which makes it become a neurodegenerative disease associated marker protein. From the current research status at homeland and abroad, and around the relationship between the expression of TDP-43 and brain injury, this article emphatically probes into the specific expression and function of TDP-43 in acute and chronic brain injury based on the knowledge of its biological characteristics, which aims to explore the feasibility for determining the cause of death and the injury and disability situations by TDP-43 in forensic pathology.
