Research Progress of the Correlation between Caveolin and Unexpected Sudden Cardiac Death.
10.3969/j.issn.1004-5619.2017.03.015
- Author:
Fang Yu WU
1
;
Lian Lei GAI
2
;
Xiao Ping KONG
3
;
Bo HAO
1
;
Er Wen HUANG
1
;
He SHI
4
;
Li Hui SHENG
5
;
Li QUAN
1
;
Shui Ping LIU
1
;
Bin LUO
1
Author Information
1. Department of Forensic Pathology, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510080, China.
2. Huangpu Branch of Guangzhou Municipal Public Security Bureau, Guangzhou 510530, China.
3. Panyu Branch of Guangzhou Municipal Public Security Bureau, Guangzhou 511430, China.
4. Guangzhou Institute of Criminal Science and Technology, Guangzhou 510030, China.
5. Institute of Criminal Science and Technology, Shenzhen Municipal Public Security Bureau, Shenzhen 518008, China.
- Publication Type:Review
- Keywords:
arrhythmias, cardiac;
caveolin;
death, sudden, cardiac;
forensic pathology;
ion channel;
review
- MeSH:
Arrhythmias, Cardiac/physiopathology*;
Autopsy;
Caveolins/metabolism*;
Channelopathies/genetics*;
Death, Sudden, Cardiac/pathology*;
Forensic Pathology;
Humans;
Ion Channels/metabolism*;
Mutation;
Myocardium
- From:
Journal of Forensic Medicine
2017;33(3):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Due to the negative autopsy and without cardiac structural abnormalities, unexpected sudden cardiac death （USCD） is always a tough issue for forensic pathological expertise. USCD may be associated with parts of fatal arrhythmic diseases. These arrhythmic diseases may be caused by disorders of cardiac ion channels or channel-related proteins. Caveolin can combine with multiple myocardial ion channel proteins through its scaffolding regions and plays an important role in maintaining the depolarization and repolarization of cardiac action potential. When the structure and function of caveolin are affected by gene mutations or abnormal protein expression, the functions of the regulated ion channels are correspondingly impaired, which leads to the occurrence of multiple channelopathies, arrhythmia or even sudden cardiac death. It is important to study the effects of caveolin on the functions of ion channels for exploring the mechanisms of malignant arrhythmia and sudden cardiac death.
