The Role of Segmental Analysis of Clonazepam in Hair in Drug Facilitated Cases.
10.3969/j.issn.1004-5619.2017.03.008
- Author:
Hang CHEN
1
;
Ping XIANG
1
;
Min SHEN
1
Author Information
1. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Institute of Forensic Science, Ministry of Justice, PRC, Shanghai 200063, China.
- Publication Type:Journal Article
- Keywords:
analytic;
chemistry;
clonazepam;
drug facilitated crimes;
forensic toxicology;
hair
- MeSH:
Adult;
Chromatography, Liquid;
Clonazepam/analysis*;
Crime;
Forensic Medicine/methods*;
Forensic Toxicology;
Hair/chemistry*;
Humans;
Mass Spectrometry;
Spectrometry, Mass, Electrospray Ionization;
Substance Abuse Detection/methods*;
Ultrasonics
- From:
Journal of Forensic Medicine
2017;33(3):252-257
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To infer the frequency of dosage and medication history investigate of the victims in drug facilitated cases by the segmental analysis of clonazepam in hair.
METHODS:Freezing milling under liquid nitrogen environment combined with ultrasonic bath was used as sample pretreatment in this study, and liquid chromatography-tandem mass spectrometry was used for the segmental analysis of the hair samples collected from 6 victims in different cases. The concentrations of clonazepam and 7-aminoclonazepam were detected in each hair section.
RESULTS:Clonazepam and its metabolite 7-aminoclonazepam were detected in parts of hair sections from the 6 victims. The occurrence time of drug peak concentration was consistent with the intake timing provided by victims.
CONCLUSIONS:Segmental analysis of hair can provide the information of frequency of dosage and intake timing, which shows an unique evidential value in drug facilitated crimes.
