Microdeletion and Mutation of Y Chromosome in Full Sibling Identification.
10.3969/j.issn.1004-5619.2016.06.011
- Author:
Qin SU
1
;
Fan BU
2
;
Chong CHEN
3
;
Yan SHI
3
;
Zhi Yong LU
1
;
Ya Cheng LIU
3
Author Information
1. Forensic Science Service of Beijing Public Security Bureau, Beijing 100192, China.
2. Criminal Investigation Detachment, Xicheng Branch of Beijing Public Security Bureau, Beijing 100055, China.
3. Beijing Tongda Shoucheng Institute of Forensic Science, Beijing 100192, China.
- Publication Type:Journal Article
- Keywords:
Y chromosome;
chromosome deletion;
forensic genetics;
mutation;
sibling relations
- MeSH:
Alleles;
Chromosome Aberrations;
Chromosomes, Human, Y/genetics*;
Discriminant Analysis;
Forensic Genetics;
Humans;
Male;
Polymerase Chain Reaction;
Sequence Deletion;
Siblings
- From:
Journal of Forensic Medicine
2016;32(6):438-440
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To explore the identification method of full sibling between two males with microdeletion and mutation of Y chromosome.
METHODS:DNA were extracted from two samples. The type testing of Y-STR and autosomal STR were performed. Full sibling between two individuals was calculated by IBS, ITO and discriminant functions methods.
RESULTS:There were 2 loci mutations existed in 33 Y-STR loci and one of the two samples had 19 loci deletions. The IBS of two samples was 53 and greater than the threshold which was 42; FSI was 1.36×10¹⁶ and far greater than 19. The discriminant function of full sibling-unrelated individual DFS2 was greater than DR2, which meant the two individuals tend to be full sibling.
CONCLUSIONS:The methods of IBS, ITO and discriminant functions of full sibling-unrelated individual can be used comprehensively to provide more reliable expert opinion in microdeletion and mutation of Y chromosome in full sibling identification.
