Effect of the Chinese Herbal Medicinal Ingredients in Huoxiang Zhengqi Liquid on Alcohol Metabolism in Rats.
10.3969/j.issn.1004-5619.2016.06.007
- Author:
Si Huo ZENG
1
;
Jun Xing OU
2
;
Juan Hua GU
1
;
Kai Run YANG
1
;
Rui WANG
1
;
Zhi LI
3
;
Shu Hua LI
1
;
Rui Lin ZHANG
1
Author Information
1. School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
2. Criminal Investigation Corps, Public Security Department of Yunnan Province, Kunming 650228, China.
3. Traffic Police Branch, Kunming Public Security Bureau, Kunming 650031, China.
- Publication Type:Journal Article
- Keywords:
Huoxiang Zhengqi liquid;
chromatography, gas;
ethanol;
forensic toxicology;
pharmacokinetics
- MeSH:
Animals;
Drugs, Chinese Herbal/pharmacology*;
Ethanol/pharmacokinetics*;
Rats
- From:
Journal of Forensic Medicine
2016;32(6):424-427
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To study the changes of alcohol content and pharmacokinetic parameter in rats after taking Huoxiang Zhengqi liquid.
METHODS:The rats were randomly divided into three groups and given with white alcohol at the dose of 3.0 mL/kg, low-dose and high-dose Chinese medicine liquor, respectively. The blood was collected before administration and 5 min, 10 min, 15 min, 30 min, 1 h, 2 h, 3 h, 4 h, 5 h, 6 h and 8 h after administration by cutting rats' tails. The concentrations of alcohol in blood were detected by headspace-gas chromatography method. The main pharmacokinetic parameters were calculated by DAS 2.0, and then analyzed by SPSS 17.0.
RESULTS:The difference of maximum blood concentrations between high-dose Chinese medicine alcohol group and white alcohol group was statistically significant （P<0.05）. There was no significant difference in other pharmacokinetic parameters among three groups （P>0.05）.
CONCLUSIONS:The Chinese herbal medicinal ingredients in the Huoxiang Zhengqi liquid has no effect on the metabolism and elimination of ethanol in rats. The research provides useful reference for the qualitative assessment and processing of traffic accident cases involved in Huoxiang Zhengqi liquid and the studies related to drug-interaction.
