Research Progress on Gene Alterations of Amelogenin Locus in Gender Identification.
10.3969/j.issn.1004-5619.2016.05.013
- Author:
Jiang Ping HUANG
1
;
Fan YANG
1
;
Ya Nan LIU
1
;
Kai Nan ZOU
1
;
Yu CAO
1
;
Dan WU
1
;
Rong Hua CHEN
1
;
Yuan PING
1
;
Huai Gu ZHOU
1
Author Information
1. Shanghai Key Laboratory of Crime Scene Evidence, Key Laboratory of Forensic Evidence and Science Technology, Ministry of Public Security, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China.
- Publication Type:Review
- Keywords:
amelogenin;
forensic genetics;
gender identification;
mutation;
review
- MeSH:
Alleles;
Amelogenin/genetics*;
Asian People/genetics*;
Chromosome Aberrations;
Chromosomes, Human, Y/genetics*;
Humans;
India;
Male;
Microsatellite Repeats;
Nepal;
Polymerase Chain Reaction;
Sequence Deletion;
Sri Lanka
- From:
Journal of Forensic Medicine
2016;32(5):371-377
- CountryChina
- Language:Chinese
-
Abstract:
There are two kinds of amelogenin gene mutation, including mutation in primer-binding region of amelogenin gene and micro deletion of Y chromosome encompassing amelogenin gene, and the latter is more common. The mechanisms of mutation in primer-binding region of amelogenin gene is nucleotide point mutation and the mechanism of micro deletion of Y chromosome encompassing amelogenin gene maybe non-allelic homologous recombination or non-homologous end-joining. Among the population worldwide, there is a notably higher frequency of amelogenin gene mutations in Indian population, Sri Lanka population and Nepalese population which reside within the Indian subcontinent. Though amelogenin gene mutations have little impact on fertility and phenotype, they might cause incorrect result in gender identification. Using composite-amplification kit which including autosomal STR locus, amelogenin gene locus and multiple Y-STR locus, could avoid wrong gender identification caused by amelogenin gene mutation.
