Research Progress on Abused Drugs Metabolic in vivo.
10.3969/j.issn.1004-5619.2016.04.013
- Author:
Bi Fen DING
1
;
Lei SHAO
2
;
Run Sheng ZHANG
3
;
Chen LIANG
3
;
Yu Rong ZHANG
3
Author Information
1. College of Life and Environmental Sciences, Shanghai Normal University, Shanghai 200234, China.
2. State Key Laboratory of Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200040, China.
3. Shanghai Key laboratory of Crime Scene Evidence, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China.
- Publication Type:Review
- Keywords:
drugs;
forensic toxicology;
metabolism;
review [publication type]
- MeSH:
Alcohol Oxidoreductases/metabolism*;
Animals;
Carboxylesterase/metabolism*;
Catechol O-Methyltransferase/metabolism*;
Cholinesterases/metabolism*;
Cytochrome P-450 Enzyme System/metabolism*;
Glucuronosyltransferase/metabolism*;
Humans;
Illicit Drugs/metabolism*;
Oxidation-Reduction;
Sulfotransferases/metabolism*
- From:
Journal of Forensic Medicine
2016;32(4):290-295
- CountryChina
- Language:Chinese
-
Abstract:
Under the catalysis of a variety of metabolic enzymes in vivo, such as UDP-glucuronyl transferases, cytochrome P450, carboxylesterase, sulfotransferase, butyrylcholinesterase, catechol-O-methyl transferase and 6-morphine dehydrogenase, the drugs perform glucuronidation, hydrolysis, oxidation, sulfonation and other reactions, then translate into active or inactive metabolites, which are excreted through urination, bile or the other pathways at last. Different drugs own their different metabolic pathways. This paper introduces the studies about the metabolism of drugs in human and animal in recent years, such as morphine-like drugs, amphetamine, ketamine, cannabis and cocaine, and reviews the research progress about the sites of metabolism, metabolic enzymes, metabolites and physiological activity of those drugs metabolic in vivo.
