Combined Genome-Wide Linkage and Association Analyses of Fasting Glucose Level in Healthy Twins and Families of Korea.
10.3346/jkms.2013.28.3.415
- Author:
Young Ju SUH
1
;
Sunghwan KIM
;
So Hun KIM
;
Jia PARK
;
Hyun Ae LIM
;
Hyun Ju PARK
;
Hangseok CHOI
;
Daniel NG
;
Mi Kyeong LEE
;
Moonsuk NAM
Author Information
1. Institute of Clinical Research, Inha University School of Medicine, Incheon, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Fasting Glucose Level;
Genome-Wide;
Genetic Linkage;
PRKCB1;
PTPRA
- MeSH:
Adult;
Aged;
Asian Continental Ancestry Group/*genetics;
Blood Glucose/*genetics;
Chromosomes, Human, Pair 15/genetics;
Chromosomes, Human, Pair 16/genetics;
Chromosomes, Human, Pair 2/genetics;
Chromosomes, Human, Pair 20/genetics;
Cohort Studies;
Family;
Female;
*Genetic Linkage;
*Genome-Wide Association Study;
Genotype;
Humans;
Male;
Middle Aged;
Polymorphism, Single Nucleotide;
Protein Kinase C/genetics;
Quantitative Trait Loci;
Receptor-Like Protein Tyrosine Phosphatases, Class 4/*genetics;
Republic of Korea;
Twins, Monozygotic/*genetics
- From:Journal of Korean Medical Science
2013;28(3):415-423
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was undertaken to identify genetic polymorphisms that are associated with the risk of an elevated fasting glucose (FG) level using genome-wide analyses. We explored a quantitative trait locus (QTL) for FG level in a genome-wide study from a Korean twin-family cohort (the Healthy Twin Study) using a combined linkage and family-based association analysis approach. We investigated 1,754 individuals, which included 432 families and 219 pairs of monozygotic twins. Regions of chromosomes 2q23.3-2q31.1, 15q26.1-15q26.3, 16p12.1, and 20p13-20p12.2, were found to show evidence of linkage with FG level, and several markers in these regions were found to be significantly associated with FG level using family-based or general association tests. In particular, a single-nucleotide polymorphism (rs6138953) on the PTPRA gene in the 20p13 region (combined P = 1.8 x 10(-6)) was found to be associated with FG level, and the PRKCB1 gene (in 16p12.1) to be possibly associated with FG level. In conclusion, multiple regions of chromosomes 2q23.3-2q31.1, 15q26.1-15q26.3, 16p12.1, and 20p13-20p12.2 are associated with FG level in our Korean twin-family cohort. The combined approach of genome-wide linkage and family-based association analysis is useful to identify novel or known genetic regions concerning FG level in a family cohort study.
