A study of genetic polymorphism of the STR locus D2S441 in Chinese Han population in Chengdu.
- Author:
Daixin HUANG
1
;
Lin ZHANG
;
Mei Yun WU
;
Guo Di CHEN
;
Yu Bo CHEN
Author Information
1. Department of Forensic Biology, West China University of Medical Sciences, Chengdu, Sichuan 610041.
- Publication Type:Journal Article
- MeSH:
Alleles;
Asian People/genetics*;
China;
Forensic Medicine;
Genetics, Population;
Genotype;
Humans;
Polymorphism, Genetic;
Tandem Repeat Sequences
- From:
Journal of Forensic Medicine
2001;17(1):15-62
- CountryChina
- Language:Chinese
-
Abstract:
Using PCR and PAG, followed by silver staining, the tetrameric STR D2S441 locus was studied in 260 unrelated Chinese individuals living in Chengdu. 9 alleles and 26 genotypes were observed. The range of fragment size was 131 bp to 155 bp. The genotype distribution of D2S441 locus in Han population was in accordance with Hardy-Weinberg equilibrium. Family survey confirmed Mendelian inheritance of alleles. The discriminating power (Dp), observed heterozygosity (H), polymorphism information content (PIC) and power of exclusion (PE) were 0.9084, 0.7885, 0.7390 and 0.5778 respectively. The results demonstrated that this locus was highly polymorphic and could be used for forensic identification and paternity testing.
