The alternative splicing & expression of fibronectin IIIcs segment and its relationship with wound healing.
- Author:
Yan JI
1
;
Zi Qin ZHAO
Author Information
1. Department of Forensic Medicine, Medical Center of Fudan University, Shanghai 200032. jigi0412@yahoo.com
- Publication Type:Review
- MeSH:
Alternative Splicing;
Animals;
Cattle;
Fibronectins/physiology*;
Forensic Medicine;
Humans;
Rats;
Wound Healing/physiology*
- From:
Journal of Forensic Medicine
2001;17(4):245-248
- CountryChina
- Language:Chinese
-
Abstract:
Fibronectin is an important large adhesive glycoprotein of the extracellular matrix, which is alternatively spliced in three regions, designated EIIIA, EIIIB and IIIcs respectively. IIIcs contains two binding domains for a variety of cell surface and extracellular ligands. Through this multiplicity of adhesive activities, IIIcs can fulfill key roles in a broad spectrum of physiological processes, such as cell spreading and migration, differentiation and embryogenesis, wound healing, malignant transformation and metastasis, etc. Here, we will discuss the structure, biological property, and function of IIIcs splicing variants and its forensic applications.
