Chinese multidisciplinary expert consensus on the management of adverse drug reactions associated with savolitinib.
10.3760/cma.j.cn112152-20221226-00853
- Author:
Li ZHANG
1
;
Yong Sheng WANG
2
;
Li Zhu LIN
3
;
Yong Feng YU
4
;
Shun LU
4
Author Information
1. Department of Respiratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100005, China.
2. Department of Oncology, West China Hospital, Sichuan University, Chengdu 610044, China.
3. Department of Oncology, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
4. Department of Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
- Publication Type:Journal Article
- Keywords:
Adverse reactions;
Consensus;
MET;
Malignant tumor;
Savolitinib
- MeSH:
Humans;
Carcinoma, Non-Small-Cell Lung/genetics*;
Lung Neoplasms/pathology*;
Consensus;
Quality of Life;
Proto-Oncogene Proteins c-met/genetics*;
Protein Kinase Inhibitors/adverse effects*;
Drug-Related Side Effects and Adverse Reactions;
Mutation
- From:
Chinese Journal of Oncology
2023;45(4):298-312
- CountryChina
- Language:Chinese
-
Abstract:
MET gene is a proto-oncogene, which encodes MET protein with tyrosine kinase activity. After binding to its ligand, hepatocyte growth factor, MET protein can induce MET dimerization and activate downstream signaling pathways, which plays a crucial role in tumor formation and metastasis. Savolitinib, as a specific tyrosine kinase inhibitor (TKI) targeting MET, selectively inhibits the phosphorylation of MET kinase with a significant inhibitory effect on tumors with MET abnormalities. Based on its significant efficacy shown in the registration studies, savolitinib was approved for marketing in China on June 22, 2021 for the treatment of advanced non-small cell lung cancer with MET 14 exon skipping mutations. In addition, many studies have shown that MET TKIs are equally effective in patients with advanced solid tumors with MET gene amplification or MET protein overexpression, and relevant registration clinical studies are ongoing. The most common adverse reactions during treatment with savolitinib include nausea, vomiting, peripheral edema, pyrexia, and hepatotoxicity. Based on two rounds of extensive nationwide investigations to guide clinicians, the consensus is compiled to use savolitinib rationally, prevent and treat various adverse reactions scientifically, and improve the clinical benefits and quality of life of patients. This consensus was prepared under the guidance of multidisciplinary experts, especially including the whole-process participation and valuable suggestions of experts in Traditional Chinese Medicine, thus reflecting the clinical treatment concept of integrated Chinese and western medicines.
