A Case of Pretibial Myxedema.
- Author:
Eun Jung CHUNG
;
Dae Gyu BYUN
;
Hyung Ok KIM
;
Chung Won KIM
;
Won HOUH
- Publication Type:Case Report
- MeSH:
Fluocinolone Acetonide;
Graves Disease;
Humans;
Hyaluronic Acid;
Hydrogen-Ion Concentration;
Immunoglobulin G;
Long-Acting Thyroid Stimulator;
Middle Aged;
Mucins;
Myxedema*;
Occlusive Dressings;
Skin;
Thyroid Gland;
Thyrotoxicosis
- From:Korean Journal of Dermatology
1981;19(6):969-973
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pretibial myxedema is a condition in which there is loeal thickening of the skin by a mucin-like deposit; it is nearly always asosciated with ophthalmopathy and thyrotoxicosis, not infrequently becomes more pronounced after treatrnent of thyrotoxicosis. The precise cause of pretibial myxedema is not known, but it appears that IgG LATS represents an autoantibody against a thyroid antigen, retroorbital tiesue and tbe skin, so, pretibial myxedema is presumed to be the result of a local antigen-antibody tissue reaction. A 57-year-old man had the history of diabetes since 1964 and Graves disease since May 1980, he was treated with metimazole for 1 month, with improving thyrotoxicosis but developed the pretibial myxedema. The histologic findings showed considerable amount of mucin, especially hyaluronic acid with toluidin blue stain at PH 3.0. The lesions were improved by local application of 0.01 x fluocinolone acetonide ointment with occlusive dressing technique.
