Therapeutic Effect fo Intra atrerial Reserpine in CRST Syndrome.
- Author:
Jae Woo PARK
;
Sook Ja SON
;
Shil SHIN
- Publication Type:Case Report
- MeSH:
CREST Syndrome*;
Deglutition;
Elbow;
Female;
Forearm;
Hand;
Humans;
Knee Joint;
Middle Aged;
Neck;
Reserpine*;
Skin;
Strikes, Employee;
Telangiectasis
- From:Korean Journal of Dermatology
1981;19(6):983-987
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The CRST syndrome, first reported by Winterbauer, represents a benign variant of scleroderma and consists of calcinosis(C), Raynauds phenomenon(R), sclerodactyly(S) and telangiectasia(T). The authors report a case of CRST syndrome confirmed by both clinical and histopathological findings. A 62-year-old female developed subcutaneous nodules on both elbow and knee joints, Raynauds phenomenon, sclerodactyly with acrosclerosis and scleroderrnatous changes on both hands and forearms and telangiectasia on the face, neck, and hands of 15 years duration, but she had no difficulty in swallowing. The authors treated a case of CRST syndrome with weekly intra-arterial administration of reserpine and were impressed not only by the marked loosening of the skin but also by the striking effect on the Raynauds phenornena; the latter disappeared within a few weeks of treatment.
