Clinical characteristics of 11 patients with chronic lymphocytic leukemia with t (14;19) (q32;q13).
10.3760/cma.j.issn.0253-2727.2023.05.011
- Author:
Cheng Hua CUI
1
;
Ya Nan CHANG
1
;
Ji ZHOU
1
;
Cheng Wen LI
1
;
Hui Jun WANG
1
;
Qi SUN
1
;
Yu Jiao JIA
1
;
Qing Hua LI
1
;
Ting Yu WANG
1
;
Lu Gui QIU
1
;
Shu Hua YI
1
Author Information
1. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
- Publication Type:Journal Article
- Keywords:
IGH::BCL3;
Leukemia, lymphocytic, chronic;
Prognosis;
t (14;
19) (q32;
q13)
- MeSH:
Humans;
Leukemia, Lymphocytic, Chronic, B-Cell/genetics*;
Retrospective Studies;
Translocation, Genetic;
Chromosome Aberrations;
Karyotyping
- From:
Chinese Journal of Hematology
2023;44(5):418-423
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the clinicopathological characteristics of 11 cases of chronic lymphocytic leukemia (CLL) with t (14;19) (q32;q13) . Methods: The case data of 11 patients with CLL with t (14;19) (q32;q13) in the chromosome karyotype analysis results of the Blood Diseases Hospital, Chinese Academy of Medical Sciences from January 1, 2018, to July 30, 2022, were retrospectively analyzed. Results: In all 11 patients, t (14;19) (q32;q13) involved IGH::BCL3 gene rearrangement, and most of them were accompanied by +12 or complex karyotype. An immunophenotypic score of 4-5 was found in 7 patients and 3 in 4 cases. We demonstrated that CLLs with t (14;19) (q32;q13) had a mutational pattern with recurrent mutations in NOTCH1 (3/7), FBXW7 (3/7), and KMT2D (2/7). The very-high-risk, high-risk, intermediate-risk, and low-risk groups consisted of 1, 1, 6, and 3 cases, respectively. Two patients died, 8 survived, and 2 were lost in follow-up. Four patients had disease progression or relapse during treatment. The median time to the first therapy was 1 month. Conclusion: t (14;19) (q32;q13), involving IGH::BCL3 gene rearrangement, is a rare recurrent cytogenetic abnormality in CLL, which is associated with a poor prognosis.
