Incidence and clinical characteristics of engraftment syndrome after syngeneic hematopoietic stem cell transplantation in patients with hematological diseases.
10.3760/cma.j.issn.0253-2727.2023.04.005
- Author:
Rui LOU
1
;
Lan Ping XU
1
;
Xiao Hui ZHANG
1
;
Kai Yan LIU
1
;
Yu WANG
1
;
Chen Hua YAN
1
;
Xiao Jun HUANG
1
;
Yu Qian SUN
1
Author Information
1. Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing 100044, China.
- Publication Type:Journal Article
- Keywords:
Clinical picture;
Engraftment syndrome;
Syngeneic hematopoietic stem cell transplantation;
syngeneic
- MeSH:
Humans;
Retrospective Studies;
Incidence;
Graft vs Host Disease/etiology*;
Hematopoietic Stem Cell Transplantation/adverse effects*;
Hematologic Diseases/complications*
- From:
Chinese Journal of Hematology
2023;44(4):289-294
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the incidence and clinical characteristics of engraftment syndrome (ES) after syngeneic hematopoietic stem cell transplantation (syn-HSCT) in patients with hematological diseases. Methods: The clinical data of 21 patients who received syn-HSCT at People's Hospital of Peking University from January 1994 to May 2018 were retrospectively analyzed. Results: Seven (33.3% ) of 21 patients developed ES. The onset of ES symptoms occurred at a median of 8 (range: 5-13) days after HSCT, and the diagnosis of ES occurred at a median of 10 (range: 7-14) days after HSCT. Steroids were administered immediately after the diagnosis of ES, the median time of symptom continuance was 2 (range: 1-5) days, and all patients showed complete resolution of ES symptoms. In the multivariate analysis, patients with acute myeloid leukemia and faster neutrophil reconstitution were the risk factors for ES (HR=15.298, 95% CI 1.486-157.501, P=0.022, and HR=17.459, 95% CI 1.776-171.687, P=0.014) . Meanwhile, there was no significant difference in the overall survival and disease-free survival between patients with ES and those without ES. Conclusion: A high incidence of ES was observed in syn-HSCT recipients. Moreover, the prognosis of ES was excellent.
