Chinese Medicine in Intervention in Signaling Pathways Related to Flap Revascularization： A Review
10.13422/j.cnki.syfjx.202202228
- VernacularTitle:中药干预皮瓣血管再生相关信号通路研究进展
- Author:
Xiaotao WEI
1
;
Zhijun HE
2
;
Tao LIU
2
;
Bo HE
1
;
Suilu MA
1
;
Weiwei WANG
1
Author Information
1. Gansu University of Chinese Medicine，Lanzhou 730000，China
2. Gansu Provincial Hospital of Traditional Chinese Medicine，Lanzhou 730000，China
- Publication Type:Journal Article
- Keywords:
revascularization;
flap ischemia-reperfusion injury;
flap repair;
signaling pathway;
Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(19):275-282
- CountryChina
- Language:Chinese
-
Abstract:
Flap surgery is an important method to repair large open wounds in trauma and plastic surgery. However， flap necrosis is a common issue. Good blood circulation that provides nutrition is a necessary condition for the survival of the flap. Promoting revascularization， establishing blood circulation， and restoring blood perfusion as soon as possible after flap transplantation is crucial for flap survival. However， revascularization/blood reperfusion can cause flap ischemia-reperfusion injury （FIRI） after flap repair. If FIRI is not treated correctly and timely， it can cause flap necrosis and graft failure eventually. Previous studies have shown that the signaling pathways related to cell proliferation and apoptosis， such as the Notch signaling pathway， mitogen-activated protein kinase （MAPK） signaling pathway， and phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt） signaling pathway， and inflammation-related pathways， such as nuclear factor E2-related factor 2 （Nrf2） signaling pathway， and nuclear factor-κB （NF-κB） signaling pathway can promote angiogenesis， improve local blood supply， inhibit the production and expression of inflammatory mediators， reduce oxidative stress and apoptosis， relieve ischemia-reperfusion injury （IRI）， and promote rapid healing after flap repair. By consulting a large number of modern medical research literature， this study reveals that both Chinese medicine monomers and Chinese medicine compounds can promote revascularization， restore blood perfusion， and accelerate healing after flap repair by regulating the expression of key protein molecules in the above-mentioned signaling pathways. This study summarized the research status in China and abroad， aiming to provide references for the in-depth study and clinical application of Chinese medicine to promote the healing of skin flaps after repair.
