Progress of Research on Tumor Extracellular Matrix and Discoidin Domain Receptor 1
10.3971/j.issn.1000-8578.2023.23.0247
- VernacularTitle:肿瘤细胞外基质及盘状结构域受体1研究进展
- Author:
Yixiao XIONG
1
;
Shengli YANG
;
Wanguang ZHANG
Author Information
1. Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
- Publication Type:Research Article
- Keywords:
Tumor microenvironment;
Extracellular matrix;
Discoidin domain receptor 1
- From:
Cancer Research on Prevention and Treatment
2023;50(8):800-807
- CountryChina
- Language:Chinese
-
Abstract:
Tumor extracellular matrix (ECM) is the center component of tumor microenvironment (TME), ECM diversity constitutes the inherent heterogeneity of TME that contributes to tumor growth, dormancy, drug resistance, and metastasis. Discoidin domain receptor 1 is one of the ECM receptors that interact with multiple ECM ligands. It also regulates the occurrence and development of tumors. Accordingly, DDR1 plays an increasingly important role in the prevention, diagnosis, and treatment of cancer. In this review, we primarily summarize the research of ECM and its receptors with components, regulation, cell receptors, and signaling pathways in tumor progression.
