Research Progress on Genetic Susceptibility to Triple-Negative Breast Cancer
10.3971/j.issn.1000-8578.2023.22.1463
- VernacularTitle:三阴性乳腺癌遗传易感性研究进展
- Author:
Lijia ZHANG
1
;
Jiarui LIU
;
Yuan ZHANG
;
Xinyu CHEN
;
Xin WANG
;
Yi ZHANG
Author Information
1. Public Health College, Zunyi Medical University, Zunyi 563000, China
- Publication Type:Research Article
- Keywords:
Triple-negative breast cancer;
Epidemic profile;
Susceptibility genes;
Genetic polymorphism;
Biomarker
- From:
Cancer Research on Prevention and Treatment
2023;50(8):794-799
- CountryChina
- Language:Chinese
-
Abstract:
Triple-negative breast cancer (TNBC) is a type of breast cancer that is difficult to treat, has a poor prognosis, and is prone to recurrence and metastasis in the early postoperative period. The age of patients is tending younger, and the racial difference is large. It is also related to family history, and genetic susceptibility is obvious. So, elucidating the genetic risk factors of TNBC and obtaining precise therapeutic targets are urgent tasks. Obtaining reliable characteristic genes and their polymorphisms between TNBC of different subtypes is difficult. This review summarizes the susceptibility genes and the polymorphisms of TNBC susceptibility genes of different molecular subtypes, in order to develop effective TNBC prevention strategies and find effective therapeutic targets. This review provides a theoretical basis for promoting the study of TNBC from the perspective of genetics.
