RNA Modification in Carcinogenesis and Development of Gastric Cancer

VernacularTitle:RNA修饰在胃癌发生发展中的作用机制研究进展
Author: Jiawen XU ¹ ; Qiang WANG ; Shouyu WANG
Author Information

1. Medical School of Nanjing University, Nanjing 210093, China
Publication Type:Research Article
Keywords: RNA modification; Gastric cancer; m6A; m5C; ac4C
From: Cancer Research on Prevention and Treatment 2023;50(8):738-744
CountryChina
Language:Chinese
Abstract: The occurrence of gastric cancer is closely related to environmental, genetic, and epigenetic factors. Currently, RNA modification is a research frontier and hotspot in the field of epigenetics. With the advancements in analytical chemistry and high-throughput sequencing technologies, new technologies and methods of exploring RNA modification are constantly being presented. Numerous studies have confirmed the involvement of RNA modifications in the occurrence and development of various diseases. Recent studies have shown that RNA modifications such as m6A, m5C, and ac4C regulate the malignant progression of various tumors, including gastric cancer, liver cancer, colorectal cancer, and leukemia. This article systematically reviews the research status and mechanism of different RNA modifications in the occurrence and development of gastric cancer, as well as discusses its potential value in the diagnosis and treatment of gastric cancer.