Research progress on the mechanism of Hippo signaling pathway in organ regeneration
10.12206/j.issn.2097-2024.202301008
- VernacularTitle:Hippo 信号通路在器官再生过程中的作用机制研究进展
- Author:
Shuai CHEN
1
;
Anpeng LI
1
;
Xingxing LI
2
;
Qingjie ZHAO
1
;
Yan ZOU
1
Author Information
1. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
2. 92805 Military Hospital, Qingdao 266300, China.
- Keywords:
Hippo signaling pathway;
organ regeneration;
target;
inhibitor
- From:
Journal of Pharmaceutical Practice
2023;41(8):472-477
- CountryChina
- Language:Chinese
-
Abstract:
Hippo signal pathway is one of the main signal pathways regulating cell proliferation and apoptosis in multicellular animals, which plays a vital role in the maintenance of tissue homeostasis and the regulation of organ growth. Most mammals have limited regenerative potential, and recent studies have shown that Hippo signal pathway is critical in the regeneration of various tissues and organs. The role of Hippo signaling pathway in organ regeneration and the research progress of related targets were introduced, the mechanism of Hippo signaling pathway promoting regeneration analyzes were aralyzed in this review, which provide theoretical reference for the treatment of diseases related to organ regeneration.
