Review of bone metabolism regulated by intestinal flora and the application of Traditional Chinese Medicine
10.12206/j.issn.2097-2024.202204059
- VernacularTitle:肠道菌群调控骨代谢及中药应用研究进展
- Author:
Weiqing FAN
1
,
2
;
Tianshuang XIA
2
;
Yiping JIANG
2
;
Hua NIAN
3
;
Hailiang XIN
2
Author Information
1. Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
2. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
3. Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
- Keywords:
intestinal flora;
SCFAs;
bone metabolism;
osteoporosis
- From:
Journal of Pharmaceutical Practice
2023;41(8):459-464
- CountryChina
- Language:Chinese
-
Abstract:
As a complex and large microbial community colonized in the human body, the intestinal flora and its metabolites short-chain fatty acids (SCFAs) play an important role in participating in human metabolism, resisting pathogens, and regulating immune mechanisms. In recent years, many studies have found that the intestinal flora is closely related to bone metabolism. The intestinal flora is able to regulate bone metabolism and affect bone mass changes through various pathways such as absorption of nutrition, generation of SCFAs, regulation of immunity, and influence on body metabolism. The potential pathways and mechanisms by which intestinal flora affect bone mass changes were reviewed in this article in bone metabolism. The related study on Traditional Chinese Medicine that has effects in balancing intestinal flora for regulating bone metabolism was also introduced in order to provide new ideas for the prevention and treatment of osteoporosis, a disease related to bone metabolism.
