RUNX1::RUNX1T1 Fusion in Pediatric Acute Myeloid Leukemia: A description of two cases.

Author: Jill Jaime ¹ ; Ivy Mae Medalla ² ; Steffanie Charlyne Tamayo ³ ; Qareem Pido ¹ ; Francisco Tria IV ^{1
,

3} ; Ma. Luisa Enriquez ³ ; Jean Kamil Sy ¹ ; Reynaldo De Castro Jr. ¹ ; Daphne Ang ^{1
,

3}
Author Information

1. Philippine Childrens Medical Center, Quezon City, Philippines
2. Eastern Visayas Medical Center, Tacloban City, Leyte, Philippines
3. St. Lukes Medical Center, Quezon City, Philippines
Publication Type:Journal Article
Keywords: Pediatric acute myeloid leukemia; Berlin- Frankfurt-Münster (BFM-87) protocol; l,AML 15 Medical Research Council protocol
MeSH: Next Generation Sequencing; RUNX1::RUNX1T1 fusion
From: Philippine Journal of Pathology 2023;8(1):42-48
CountryPhilippines
Language:English
Abstract: RUNX1::RUNX1T1 is a core-binding factor driving fusion gene which arises from t(8;21)(q22;q22). It is one of the most common chromosomal rearrangements in both pediatric and adult Acute Myeloid Leukemia (AML) with a reported incidence o 15% in children and young adults. There are few case reports documenting RUNX1::RUNX1T1 translocation in pediatric AML. Although this is generally associated with a favorable prognosis, we report two (2) cases of de novo pediatric AML in the Philippines harboring a RUNX1::RUNX1T1 translocation, one eventually relapsed while the other attained remission but succumbed to sepsis.
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