Effects of neural stem cells transplantation on the behavior of Parkinson's disease mice
- VernacularTitle:神经干细胞移植对帕金森病模型小鼠行为的影响
- Author:
Anchen GUO
;
Xuekun LI
;
Jicheng YANTAI
;
Lingna KONG
;
Pingping ZUO
- Publication Type:Journal Article
- Keywords:
neural stem cells transplantation, Parkinson's disease, behavior, mice
- From:
Chinese Journal of Rehabilitation Theory and Practice
2003;9(7):399-400
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effects of neural stem cells transplantation on the behavioral deficits of Parkinson's disease mice.MethodsSpontaneous movement,Morris Water Maze and Rotarod were adopted to evaluate the behavioral changes.ResultsCompared with the control,the time of spontaneous movement was decreased,the latency of Water Maze was lengthened,and the time of Rotarod was shortened in the Parkinson's disease(PD) mice. These deficits were improved 2,4 and 8 weeks after unilateral and bilateral transplantation of neural stem cells.ConclusionsThe transplantation of neural stem cells can improve the behavioral deficits in the PD mice.
